Why you are what you eat by Inna Kruman

Inna Kruman

Phoenix, Arizona

Inna Kruman, PhD, is a researcher and author of over 50 scientific articles. Through nearly three decades she has been working in molecular and cellular neuroscience.

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About the author

Dr. Kruman grew up in USSR. She received her Ph.D. in Cellular Biology from Lomonosov Moscow State University in 1983. The last 25 years she has been working in USA. Her research interests focus on mechanisms of apoptosis and DNA damage response in postmitotic neurons. She has authored over 50 scientific publications, including articles in major peer reviewed journals such as Neuron and Journal Neuroscience, book chapters and invited reviews.

Inna grew up with two doctor parents. She was always pulled toward science and went on to earn her Master’s degree in bioorganic chemistry. In a medical chemistry course, she learned that practically all conventional drugs have side effects, and the way they impact humans are often unclear.

Even as Inna has enjoyed an academic career in life sciences, she has also always been deeply interested in the role of lifestyle factors in the underlying causes of disease. She has concurrently studied epigenetic (as opposed to genetic) factors in the progression of different diseases. Based on increasing evidence and her own experience. Inna came to the conclusion that lifestyle change is the key to finding and eliminating the cause (s) of chronic disease in the diet and environment.

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Why you are what you eat

How you eat and digest profoundly influences your mental and physical health

This book describes how diet, gut microbiome and epigenetics contribute to the regulation of immune and neuronal systems and thereby play pivotal roles in both physical and mental health.

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	Science Health
	50,000 words
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Synopsis

The concept of a tight link between food and human identity is centuries-old and is mentioned in the Old Testament. However, how food affects a human body and mind remained unclear until relatively recently when researches established that environmental factors, including diet can change gene expression. This concept of epigenetics implies that environmental factors not affecting DNA sequence can regulate gene expression by DNA modifications. Such changes could be maintained across generations. Thus, recent advances in epigenetics can explain how diet can impact health, physiology and even behavior at any point in life. Indeed, epigenetic DNA modulations are common in chronic diseases such as lupus and diabetes. Moreover, many psychiatric and neurodegenerative diseases such as Alzheimer’s, Parkinson’s, schizophrenia, and autism are also linked to epigenetics or at least have an epigenetic component. Developmental abnormalities caused by nutritional restriction are also associated with epigenetic modifications during pregnancy.

Another important aspect of dietary impact on human organism is microbiome. Certain strains of gut flora (bacteria, fungi, viruses and other microbes) play a huge role in function of digestive system. Recent studies allow for better understanding a vital role in necessary human functions. Given that 70 to 80 percent of the immune tissue “lives” in gastrointestinal tract and germ-free animals are deficient in the development of the gut-associated lymphoid tissues and exhibit decreased immune resistance to infection, the significance of gut bacteria in keeping the body healthy become increasingly evident. The gut also has its own nervous system, called the enteric nervous system. The enteric nervous system governs the function of the gut and is closely associated with the development of the central nervous system. The latest and perhaps most remarkable finding is the ability of gut bacteria to moderate brain function and behavior. Diet composition plays an important role in the control of gut microbial populations and, thus, in the prevention, management and treatment of certain diseases.

Thus, what we eat can affect gene expression at the transcriptional level and is especially important for immune system and brain function, increase or prevent most cases of certain diseases, such as stroke, diabetes, and cancer. What we eat can be also the most powerful form of medicine.

Outline

Chapter 1: The history of human diet and how diet changes, like meat eating, allowed the evolution of human large brains.

Chapter 2: Epigenetics and its role in maintaining the body's homeostasis and human diseases. How diet can change epigenome.

Chapter 3: The role of nutrition in immune function. The digestive system doesn’t only digest food, it determines a good health of the immune system

Chapter4: The role of microbiome in normal homeostasis and diseases.

Chapter 5: the enteric nervous system or the gut brain. The enteric nervous system governs the function of the gut. The intimate relationship between the brain and the enteric nervous, the Gut-Brain Axis. Changes in the gut microbiome (stress, antibiotics or toxins) negatively impact the brain.

Chapter 6: The role of digestion system and diet in allergies and autoimmune diseases.

Chapter 7: Food as medicine. Benefits of Functional medicine in prevention and treatment of chronic diseases.

Audience

My ideal audience is people who are interested in life science and people who have chronic diseases, such as allergies and immune diseases and looking for an alternative approach to the treatment. This book can also be interesting for people who want to better understand factors for good health.

A new analysis by Pew Research Center finds 37% of online adults say “health and medicine” is among the topics they find most interesting. Women are especially likely to express interest in health and medical topics, while men are relatively more inclined to express interest in science and technology. About half of online women (52%) say health and medicine is among the top three topics of interest to them, compared with 22% among men. Younger adults (ages 18 to 29) are more inclined than older adults (ages 50 to 64) to cite science and technology as a topic of particular interest, while the reverse pattern occurs when it comes to interest in health and medicine.

Promotion

I will use my personal network and email list to prepare these people before the book launch, get them engaged in feedback and of course to acquire the initial readership subsequently through pre-orders to the same people.

Connections on LinkedIN, on Facebook, my colleagues.

Competition

1.You Are What You Eat: The Plan That Will Change Your LifeGillian McKeith; March 28, 2006; Plume.

The book represents features real-life diet makeovers and case studies, easy to use lists and charts.

2. Mark Hyman M.D. Food. What the Heck Should Eat? February 27, 2018. Little, Brown and Company

Dr Hyman takes a close look at every food group and explains what we've gotten wrong, revealing which foods nurture our health and which pose a threat. Dr. Hyman debunks misconceptions and breaks down the fascinating science in his signature accessible style. He also explains food's role as powerful medicine capable of reversing chronic disease, painting a holistic picture of growing, cooking, and eating food .

3. Steven R Gundry M.D. (Author); The Plant Paradox: The Hidden Dangers in "Healthy" Foods That Cause Disease and Weight Gain; April 25, 2017; Harper Collins

Dr. Gundry reveals that gluten is just one variety of a common, and highly toxic, plant-based protein called lectin. These proteins are designed by nature to protect them from predators (including humans). Once ingested, they incite a kind of chemical warfare in our bodies, causing inflammatory reactions that can lead to serious health conditions.
Dr. Gundry has successfully treated tens of thousands of patients suffering from a variety of chronic diseases. In the Plant Paradox, Dr. Gundry shares his clinically proven program.

4. Justin Sonnenburg and Erica Sonnenburg The Good Gut: Taking Control of Your Weight, Your Mood, and Your Long-term Health. May 3, 2016. Penguin Books

Justin and Erica Sonnenburg are pioneers in the most exciting and potentially transformative field in the entire realm of human health and wellness, the study of the relationship between our bodies and the trillions of organisms representing thousands of species to which our bodies play host, the microbes that we collectively call the microbiota.

5. Lindsay Boyers The Everything Guide to Gut Health: Boost Your Immune System, Eliminate Disease, and Restore Digestive Health; January 9, 2015; Everything.

A poor gut health causes many problems. The book is an inclusive and natural guide to gut health also features 150 nutritious recipes to promote healthy gut flora. The book offers 150 nutritious recipes to restore healthy gut flora and thereby reduce or eliminate symptoms of a wide range of diseases.

6. Elizabeth Lipski; Digestive Wellness: Strengthen The Immune System And Prevent Disease Through Healthy Digestion, Fourth Edition; August 19th 2011; McGraw-Hill Education

The book explains how your digestive system works and what to do when it doesn’t. It describes practical solutions to all the common gastrointestinal disorders and expert guidance on the newest advances in testing and diagnosis, nutrition, and natural therapies.

How "Why you what you eat" is different:

I make the accent on "why" or on the scientific mechanisms of how food affects a human body, on complex relationships between digestive system with its symbiotic microbes and immune and nervous system. In my book, I focus on scientific aspects behind the reaction of digestive system to diet.
Other most relevant books are mainly centered on the practical aspects such as certain diets, protocols, clinically proven programs or nutritious recipes.

14 publishers interested

	Meyer & Meyer Sport 500 copies • Partial manuscript • Looking for topics that support amateur sports enthusiasts, coaches, elite athletes, PE teachers, sports scientists, and sports medics. Meyer & Meyer Sport was founded in 1984 and is widely acknowledged to be among the elite of sport publishers worldwide. Since then the company has grown to be the biggest sports publishing house worldwide while ensuring quality remained the best possible. The company's prime objective is to provide ideas and practical guidance to sport and leisure activities that will improve the reader's performance, enjoyment and will raise the quality of life. Topics are aimed at many different age groups, ranging from children and adolescents to adults and seniors. With a list of titles that now exceeds 2,000 titles in both English and German, written by some of the world's acknowledged experts in their individual fields, the company provides a wide range of products, from handbooks providing in-depth analysis of the subject to hints and tips for the more casual reader. Meyer & Meyer is also the home of some of the world's most prestigious academic journals and theses published in sports science. Traditional publisher Mind & Body, Biography & Memoir, Cookbooks, Food & Wine, Crafts & Hobbies, Health, Fitness & Dieting, Journalism, Mindfulness & Happiness, Motivation & Inspiration, Personal Growth & Self-Improvement, Popular Science, Science, Society & Culture, Sports & Outdoors United Kingdom, United States, Australia
	Ballast Books 250 copies • Partial manuscript. Ballast Books is a full-service hybrid publisher that handles all aspects of book creation, design, publishing, marketing, distribution, and platform building. We help our authors sell more books, secure more keynotes, do more consulting, earn more customers, and book more media appearances. We want to work with the best of the best: Former Special Operations Forces, CEOs, big thinkers, industry-leading experts. Top-performing people with experiences worth sharing and skills that translate into a larger message and goal. We've seen particular success with military memoirs, but we've also recently hired a children's book specialist, so we run the spectrum of genres. We're a small but growing team and take pride in dedicating more time and energy to all our authors than traditional publishers. Hybrid publisher All categories , United States
	Blooming Twig 500 copies • Complete manuscript. Blooming Twig is an award-winning boutique publishing house, media company, and thought leadership marketing agency. Based in New York City and Tulsa, we have represented and re-branded hundreds of thought leaders, published more than 400 titles in all genres, and built up a like-minded following for authors, speakers, trainers, and organizations with our bleeding-edge marketing strategies. Blooming Twig is about giving the people with something to say (“thought leaders”) a platform, walking its clients up to their own influencer pulpit, and making sure there is a like-minded crowd assembled to hear the meaningful message. Hybrid publisher Children Fiction, Literary Fiction, Mind & Body, Mystery, Thriller, Horror & Suspense, Science Fiction & Fantasy, YA Fiction, Biography & Memoir, Business & Money, Career & Success, Cookbooks, Food & Wine, Health, Fitness & Dieting, History, Journalism, Personal Growth & Self-Improvement, Politics & Social Sciences, Religion & Spirituality, Science, Society & Culture, Sports & Outdoors, Technology & the Future, Travel Worldwide
	Boyle & Dalton 250 copies • Completed manuscript. Boyle & Dalton was founded in 2014 and publishes works of fiction, non-fiction, and poetry. The world of publishing is changing, we're changing with it. Our founder Brad Pauquette, conceptualized a hybrid model that balances the financial and rights model of self-publishing with the quality controls and production excellence of a traditional publisher. Our designers and editors produce exceptional books that are distributed in both print and digital formats to all major retailers, including Amazon.com and BarnesandNoble.com. Boyle & Dalton carefully consider all submissions for publication, based on manuscript quality. We do not accept erotica or children's books. Hybrid publisher Christian Fiction, Comics & Graphic Novels, Commercial Fiction, Contemporary Fiction, Historical Fiction, LGBT Fiction, Literary Essay, Literary Fiction, Mind & Body, Mystery, Thriller, Horror & Suspense, Mythology & Folk Tales, Poetry, Romantic Fiction, Science Fiction & Fantasy, Women's Fiction, YA Fiction, Art & Photography, Biography & Memoir, Business & Money, Career & Success, Children Non-Fiction, Christian Non-Fiction, Coloring Books for Grown-Ups, Comics & Graphic Novels, Cookbooks, Food & Wine, Communication Skills, Corporate Culture, Crafts & Hobbies, Creativity, Current Affairs, Economics, Education, Entrepreneurship & Small Business, Health, Fitness & Dieting, History, Humor & Entertainment, Illustrated Books, Journalism, LGBT Non-Fiction, Management & Leadership, Marketing & Sales, Mindfulness & Happiness, Money & Investment, Motivation & Inspiration, Nature & Environment, Parenting, Personal Growth & Self-Improvement, Philosophy, Politics & Social Sciences, Popular Science, Productivity & Time Management, Psychology, Reference, Religion & Spirituality, Science, Sex & Relationships, Society & Culture, Sports & Outdoors, Technology & the Future, Travel, YA Non-Fiction Worldwide
	Cranthorpe Millner 250 copies • Partial manuscript. Cranthorpe Millner operates a hybrid publishing model. This means, should an author pass our editors’ strict filtering system, we can offer different kinds of agreements depending on the author and the manuscript. With some authors, we work under a ‘traditional’ model, whereby we cover the full cost of publication and the author is offered industry-standard royalties (8-10%). To some authors, we offer what we call a partnership or contributory agreement, whereby the author is asked for a financial contribution so that we may share the risk and enter into a partnership together to publish the author’s book. In this case, the author receives around 60-75% royalties. Hybrid publisher Children Fiction, Literary Fiction, Literary Fiction, Mystery, Thriller, Horror & Suspense, Mystery, Thriller, Horror & Suspense, Mind & Body, Mind & Body, Romantic Fiction, Romantic Fiction, Science Fiction & Fantasy, Science Fiction & Fantasy, YA Fiction, YA Fiction, Biography & Memoir, Biography & Memoir, Health, Fitness & Dieting, Health, Fitness & Dieting, History, History, Personal Growth & Self-Improvement, Personal Growth & Self-Improvement, Science, Science, Sports & Outdoors, Sports & Outdoors, Travel, Travel United Kingdom, United States, Canada
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	Atmosphere Press 250 copies • Partial manuscript. Atmosphere Press is an independent publisher dedicated to author rights. We publish in all genres and have an exceptional editorial, design, and promotional staff. We stand for Honesty, Transparency, Professionalism, and Kindness. We want our authors and their readers to be blown away when they first hold that book in their hands. It needs to look good inside and out, and feel good to the touch. And, of course, the words need to be top-notch, and our editors are devoted to making that the case. Service publisher Children Fiction, Literary Fiction, Mind & Body, Mystery, Thriller, Horror & Suspense, Romantic Fiction, Science Fiction & Fantasy, YA Fiction, Biography & Memoir, Business & Money, Career & Success, Cookbooks, Food & Wine, Health, Fitness & Dieting, History, Journalism, Personal Growth & Self-Improvement, Politics & Social Sciences, Religion & Spirituality, Science, Society & Culture, Sports & Outdoors, Technology & the Future, Travel Worldwide
	Authors Unite 250 copies • Partial manuscript. Authors Unite helps you become a profitable author and make an impact. We take care of printing and distribution through major online retailers, developmental editing, and proofreading with unlimited revisions. We take care of the entire process for you from book cover design all the way to set up your backend so all your book royalties go straight to your bank account. We can also help with ghostwriting if you prefer not to have to figure out all the steps on how to write a book yourself. With our book marketing services, you don’t need to worry about figuring out all the steps on how to market a book or how to become a bestselling author. We’ve helped hundreds of authors become bestselling authors on Amazon, USA Today, and The Wall Street Journal. We take care of the entire book launch process for you to help you sell thousands of copies of your book and become a bestselling author. View case studies here: https://authorsunite.com Service publisher Children Fiction, Christian Fiction, Comics & Graphic Novels, Commercial Fiction, Contemporary Fiction, Historical Fiction, LGBT Fiction, Literary Fiction, Mystery, Thriller, Horror & Suspense, Mind & Body, Mythology & Folk Tales, Romantic Fiction, Science Fiction & Fantasy, Women's Fiction, YA Fiction, Biography & Memoir, Business & Money, Career & Success, Children Non-Fiction, Christian Non-Fiction, Communication Skills, Corporate Culture, Crafts & Hobbies, Creativity, Current Affairs, Economics, Education, Entrepreneurship & Small Business, Health, Fitness & Dieting, History, Humor & Entertainment, Journalism, LGBT Non-Fiction, Management & Leadership, Marketing & Sales, Mindfulness & Happiness, Money & Investment, Motivation & Inspiration, Nature & Environment, Parenting, Personal Growth & Self-Improvement, Philosophy, Politics & Social Sciences, Popular Science, Productivity & Time Management, Psychology, Reference, Religion & Spirituality, Science, Sex & Relationships, Society & Culture, Sports & Outdoors, Technology & the Future, Travel, YA Non-Fiction, Science Fiction & Humour Worldwide
	Bookmobile 100 copies • Partial manuscript. Bookmobile provides book printing, graphic design, and other resources to support book publishers in an ever-changing environment. Superior quality, excellent customer service, flexibility, and timely turnarounds have attracted nearly 1,000 satisfied clients to Bookmobile, including trade houses, university presses, independent publishers, museums, galleries, artists, and more. In addition, we manage eBook conversions and produce galleys, and regularly provide short-run reprints of 750 copies or fewer for major publishers such as Graywolf Press. Service publisher Children Fiction, Literary Fiction, Mind & Body, Mystery, Thriller, Horror & Suspense, Romantic Fiction, Science Fiction & Fantasy, YA Fiction, Biography & Memoir, Business & Money, Career & Success, Cookbooks, Food & Wine, Health, Fitness & Dieting, History, Journalism, Personal Growth & Self-Improvement, Politics & Social Sciences, Religion & Spirituality, Science, Society & Culture, Sports & Outdoors, Technology & the Future, Travel Worldwide
	Crescendo Publishing 100 copies • Completed manuscript • Looking for novels, memoirs, fantasy, and other fiction. Crescendo Publishing is a boutique-style, concierge VIP publishing company assisting entrepreneur authors with writing, publishing, and promoting their books for the purposes of lead-generation and achieving global platform growth, then monetizing it for even more income opportunities. Service publisher Literary Fiction, Mystery, Thriller, Horror & Suspense, Mind & Body, Romantic Fiction, Science Fiction & Fantasy, YA Fiction, Biography & Memoir, Business & Money, Career & Success, Health, Fitness & Dieting, History, Journalism, Personal Growth & Self-Improvement, Politics & Social Sciences, Society & Culture, Travel Worldwide
	Happy Self Publishing 100 copies • Completed manuscript. Happy Self Publishing has helped 500+ authors to get their books self-published, hit the #1 position in the Amazon bestseller charts, and also establish their author website & brand to grow their business. And the best thing is, we do all this without taking away your rights and royalties. Let's schedule a call to discuss the next steps in your book project: www.meetme.so/jyotsnaramachandran Service publisher Children Fiction, Literary Fiction, Mind & Body, Mystery, Thriller, Horror & Suspense, Romantic Fiction, Science Fiction & Fantasy, YA Fiction, Biography & Memoir, Business & Money, Career & Success, Cookbooks, Food & Wine, Health, Fitness & Dieting, History, Journalism, Personal Growth & Self-Improvement, Politics & Social Sciences, Religion & Spirituality, Science, Society & Culture, Sports & Outdoors, Technology & the Future, Travel Worldwide
	IngramSpark Ingram is a rather large company with several different divisions and supplies books to bookstores and libraries in over 200 countries around the world. Ingram also has a print on demand digital printing company, Lightning Source. IngramSpark is the platform that combines those two services together. At IngramSpark, we work with authors and independent publishers to print their books for orders they need (no minimum order) and we have a way to list the books as available for sale to all of Ingram’s 39,000+ customers- distributors, bookstores, retail outlets, libraries, etc., so you never miss a sale. You would provide us with the print-ready digital files (one for the cover and one for the interior) and we print the books as they are sold through our distribution partner’s websites. We pay you for those sales approximately 90 days later. The compensation you earn is based on the retail price you set, minus the wholesale discount you offer our distribution partners, minus the print cost. Service publisher Children Fiction, Literary Fiction, Mind & Body, Mystery, Thriller, Horror & Suspense, Romantic Fiction, Science Fiction & Fantasy, YA Fiction, Biography & Memoir, Business & Money, Career & Success, Cookbooks, Food & Wine, Health, Fitness & Dieting, History, Journalism, Personal Growth & Self-Improvement, Politics & Social Sciences, Religion & Spirituality, Science, Society & Culture, Sports & Outdoors, Technology & the Future, Travel Worldwide
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	ShieldCrest Publishing ShieldCrest are book publishers based in the UK who fill that vital gap for talented authors where mainstream publishers are unwilling to give them that chance. We strive for excellence and invest in our authors and are listed in FreeIndex as the number one independent publisher in the UK for price quality and service rated author satisfaction. We publish books of all genres including; fiction, historical, biographies and children's books. ShieldCrest publishing continues to grow rapidly with satisfied authors throughout the UK and overseas. Our range of products includes paperbacks, hardbacks and digitised e-books in all formats used globally in the myriad of e-readers. In addition to the above, ShieldCrest provides a complete range of services including book design and layout, illustrations, proof reading and editing. For marketing we offer author web page, press releases, social media marketing packages and many other support services to help both first time and experienced authors get their books into the market quickly and maximise on the opportunities available. These services enable us to guide our authors through the process as we transform their manuscript into a professional book, which can take its place with pride next to any famous author's book of the same genre. The staff at ShieldCrest have many years experience in the book industry and this wealth of experience is put at the disposal of our authors. Our clients include established authors such as Diane Marshall who has been acclaimed as the best writing talent to come from Scotland for years by The Scotsman newspaper, and Prof Donald Longmore OBE, who performed the first heart transplant in the UK and has sold thousands of medical books used by students throughout the world. We also recently released "Martin Foran-The Forgotten Man" by J.R. Stephenson, which features fraud within the police, abuse within the prison service and injustices in the courts and has been featured in the press and on TV. Service publisher Children Fiction, Literary Fiction, Mind & Body, Mystery, Thriller, Horror & Suspense, Romantic Fiction, Science Fiction & Fantasy, YA Fiction, Biography & Memoir, Business & Money, Career & Success, Cookbooks, Food & Wine, Health, Fitness & Dieting, History, Journalism, Politics & Social Sciences, Religion & Spirituality, Science, Society & Culture, Sports & Outdoors, Technology & the Future, Travel Worldwide

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Inna Kruman

About the author

Why you are what you eat

Synopsis

Outline

Audience

Promotion

Competition